Microglia相关论文
背景白细胞介素10（IL-10）是一种重要的抗炎细胞因子,可以促进神经元和神经胶质细胞的存活,IL-10缺失,引起了阿尔茨海默症（AD）小鼠模型......
目的:评价长期摄入ω-3多不饱和脂肪酸(ω-3 PUFAs)对术后认知功能障碍(POCD)小鼠海马小胶质细胞活化的影响。方法:清洁级健康雄性......
目的:评价肝缺血再灌注大鼠外泌体对小胶质细胞焦亡的影响。方法:清洁级健康雄性SD大鼠20只，2~3周龄，体重20~50 g，采用随机数字表法分......
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Microglial activation plays an important role in neurodegenerative diseases. Once activated, they have macrophage-like c......
N-methyl-D-aspartic acid receptor 1 (NMDAR1) aggravates secondary inflammatory damage induced by hem
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Bone marrow mesenchymal stem cell transplantation downregulates plasma level and the microglia expre
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Sex differences in traumatic brain injury: a multi-dimensional exploration in genes, hormones, cells
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胶质瘤是中枢神经系统常见的肿瘤，由于肿瘤微环境天然的免疫抑制有利于肿瘤的生长、转化和迁移，传统的治疗手段一直收效甚微，难有突破......
细胞焦亡是一种继细胞凋亡、细胞坏死及自噬之后新发现的炎性体介导的程序性促炎性反应造成细胞死亡方式，其主要信号通路包括依赖半......
早期脑损伤(early brain injury, EBI)是指蛛网膜下腔出血(subarachnoid hemorrhage, SAH)后72 h内、脑血管痉挛出现前发生的一系......
神经炎性反应是包括帕金森病(PD)在内的许多神经退行性疾病的重要病理改变之一，小胶质细胞的激活为中枢神经系统炎性反应的主要特征......
New insights into Wnt signaling alterations in amyotrophic lateral sclerosis: a potential therapeuti
Amyotrophic lateral sclerosis is a fatal neurodegenerative disorder characterized by upper and lower motor neuron degene......
Inhibiting endogenous tissue plasminogen activator enhanced neuronal apoptosis and axonal injury aft
Tissue plasminogen activator is usually used for the treatment of acute ischemic stroke, but the role of endogenous tiss......
Characterization of astrocytes and microglial cells in the hippocampal CA1 region after transient fo
Ilexonin A is a compound isolated from the root of Ilex pubescens, a traditional Chinese medicine. Ilexonin A has been s......
Green tea catechins inhibit microglial activation which prevents the development of neurological dis
The over-activated microglial cells induce neuroinflammation which has the main role in neurological disorders. The over......
目的观察环氧合酶2(Cyclooxygenase 2，COX-2)特异性抑制剂NS398对脂多糖(lipopolysaccharide，LPS)激活小胶质细胞介导的海马神经元损......
目的探讨卒中后抑郁(post stroke depression，PSD)大鼠额叶、海马及杏仁核小胶质细胞的增殖表达变化，了解小胶质细胞在PSD发病过程中......
目的通过揭示脊髓脊膜膨出(myelomeningocele，MMC)胎鼠小胶质细胞在脊髓内时空分布及相关神经元凋亡因子，以探讨脊柱裂患儿神经损伤......
目的探讨胆碱能抗炎通路对大鼠术后持续性痛及脊髓小胶质细胞活化的影响。方法成年健康雄性SD大鼠36只，按随机数字表法分为三组(n＝12......
目的研究ω-3多不饱和脂肪酸对大鼠创伤性脑损伤(TBI)后神经细胞凋亡、脑水肿、小胶质细胞活化、炎症反应及神经功能的影响，以探讨......
抑郁症已成为世界第4大疾病,其发病率仍呈逐年上升态势,严重危害公众的身心健康及生命。然而,抑郁症的发病机制仍不十分清楚。神经......
目的探讨谷氨酰胺(Gln)对大鼠创伤性颅脑损伤后神经功能损伤评分、神经元凋亡、小胶质细胞极化和神经炎症反应的影响。方法采用Fee......
目的 探讨超声灰度值测定在围产期脑白质损伤早期定量评价中的价值。方法 对生后7d内超声诊断为脑白质病变的新生儿104例及对照组4......
目的 研究[Gly14]-humanin(HNG)对脑出血(ICH)模型大鼠的神经保护作用. 方法 将健康雄性SD大鼠30只采用随机数字表法分为HNG治疗组......
目的 评价糖尿病大鼠痛性周围神经病变时脊髓小胶质细胞的活化.方法 SD大鼠25只,2月龄,雌雄不限,腹腔注射1%链脲佐菌素60 mg/kg以......
14-3-3 gamma and zeta protein expression in active microglia Immune response mechanisms of Parkinson
BACKGROUND: The progressive degeneration of dopaminergic neurons in Parkinsons disease is associated with an activated g......
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system, and microglia and macropha......
Neuropeptide Y has been shown to inhibit the immunological activity of reactive microglia in the rat cerebral cortex, to......
Inhibition of extracellular vesicle pathway using neutral sphingomyelinase inhibitors as a neuroprot
Traumatic brain injury is a sudden trauma or blow on the head,and severe traumatic brain injury is a major cause of deat......
Metformin, a first-line drug for type-2 diabetes, has been shown to improve locomotor recovery after spinal cord injury.......
Objective:To investigate the antinociceptive effect of tingenone on inflammatory pain, as well as and the involvement of......
Low-dose lipopolysaccharide as an immune regulator for homeostasis maintenance in the central nervou
Microglia, which are tissue-resident macrophages in the brain, play a central role in the brain innate immunity and cont......
In the central nervous system, immunologic surveillance and response are carried out, in large part, by microglia. These......
The contribution of chronic peripheral inflammation to the pathogenesis of neurodegenerative diseases is an outstanding ......
Effects of primary microglia and astrocytes on neural stem cells in in vitro and in vivo models of i
Transplantation of neural stem cells(NSCs)can protect neurons in animal stroke models;however,their low rates of surviva......
Traumatic brain injury (TBI) is a major cause of mortality and morbidity in the pediatricpopulation. With advances in me......
TP53-induced glycolysis and apoptosis regulator alleviates hypoxia/ischemia-induced microglial pyrop
Our previous studies have demonstrated that TP53-induced glycolysis and apoptosis regulator (TIGAR) can protect neurons ......
Microglia are brain-resident immune cells that contribute to the maintenance of brain homeostasis. In the epileptic brai......
Osteopontin is a broadly expressed pleiotropic protein, and is attracting increased attention because of its role in the......
Previous studies have shown that Ninjurin-1 participates in cell trafficking and axonal growth following central and per......
目的:探索金钗石斛多糖(NDP)对脂多糖(LPS)作用的新生大鼠大脑皮层胶质细胞-神经元混合培养体系的保护作用。方法:制备新生大鼠大......
目的探究高压力对BV2小胶质细胞促炎因子TNF-α和IL-1β表达的影响。方法使用自制加压装置干预体外培养的BV2小胶质细胞。根据干预......
Fingolimod (FTY720) improves postoperative cognitive dysfunction in mice subjected to D-galactose-in
Neurocognitive dysfunction is a common postoperative complication, especially in older adult patients. Fingolimod (FTY72......
血脑屏障在正常情况下能够保证脑的内环境的高度稳定性，以利于中枢神经系统的机能活动。中枢神经系统内缺乏各种常见的抗原递呈细胞......
目的 在脂多糖(LPS)激活的小胶质细胞(MG)基础上观察姜黄素(Cur)对BV2细胞合成单核细胞趋化因子(MCP-1)的影响,并探讨其可能的分子......
